Vaccine for the Prevention in Humans of Coldlike Symptoms Associated with the Jh Virus.

I Z. Dische, J. Biol. Chem., 167, 189, 1947. 8 J. X. Khym and D. G. Doherty, J. Am. Chem. Soc., 74, 3199, 1952. 9 In addition to the fractions shown in Table 1, a substance having an apparent glucuronic acid-hexosamine ratio of 0.62 by the carbazole method was isolated in the amount of 0.15 per cent of the wet weight from the spleen of case K. N. The nature of the hexosamine in this fraction was not investigated. Presumably, this polysaccharide belongs to a different series of compounds; it may be structurally related to chondoitin sulfate B. 10 P. Hoffman, A. Linker, and K. Meyer, Science, 124, 1252, 1956. 11 F. G. Fischer and H. Dorfel, Z. physiol. Chem., 301, 224, 1955. 12 K. S. Dodgson and B. Spencer, Biochem. J., 55, 436, 1953. 13L. Andersen, Acta. chem. Scand., 7, 689, 1953. 14 A. Elek and R. A. Harte, Anal. Chem., 8, 267, 1936. 16 J. E. Jorpes, H. Bostrom, and V. Mutt, J. Biol. Chem., 183, 607, 1950. 16 E. G. Frame, J. A. Russell, and A. E. Wilhelmi, J. Biol. Chem., 149, 255, 1943. 17 B. and M. Blomback, E. V. Corneliusson, and J. E. Jorpes, J. Pharm. and Pharmacol., 5, 1031, 1953. 18 The author is indebted to Dr. T. Weichselbaum for a gift of beef lung ammonium heparinate (156 units/mg). 19 A. Dorfman and A. E. Lorincz, these PROCEEDINGS, 43, 443, 1957. 20 K. Meyer, Abstr. 130th Am. Chem. Soc. Meetings, Sept. 1956, p. 15D.